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Interaction of [3H] corticosterone from blood serum with rat liver cells during aging

Fil'chenkov, G.N.; Naumenko, V.K.; Iakubovskiĭ, S.M.; Ostapenko, V.A.; Lastovskaia, T.G.; Konoplia, E.F.

Ukrainskii Biokhimicheskii Zhurnal 63(2): 89-94

1991

ISSN/ISBN: 0201-8470
PMID: 1882467
Document Number: 386571
It is shown that the consumption of glucocorticoids from the complexes with serum proteins by hepatocytes decreases with ageing. Transcortin-complexed decrease adenosine monophosphate binding by the liver cells but the degree of this inhibition decreases with an increase of animals' age, which is probably connected with the change in physicochemical properties of steroid-transport blood glycoprotein.

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