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The specific activity of a multicomponent vaccine made from the antigens of opportunistic microorganisms

Mansurova, N.L.; Egorova, N.B.; Kaverina, K.G.; Poliachenko, V.M.; Lobova, E.A.

Zhurnal Mikrobiologii Epidemiologii i Immunobiologii 4: 39-41

1991

ISSN/ISBN: 0372-9311
PMID: 1882605
Document Number: 386248
Multicomponent vaccine prepared from the antigens of 4 representatives of opportunistic microflora possesses high specific activity. The passive hemagglutination (PHA) test with the use of associated diagnosticum showed that antibody titers in the sera of immunized rabbits increased 10- to 10(4)-fold in comparison with the titers observed prior to immunization. The PHA test with the use of the antigens contained in the vaccine revealed the accumulation of antibodies to each of the 4 components of the preparation in the blood sera of immunized rabbits. When stored at 4 degrees C, the vaccine was shown to retain its specific activity for 5 years (the term of observation).

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