Protection against hemorrhagic pneumonia of mink by Pseudomonas aeruginosa multicomponent vaccine
Aoi, Y.; Noda, H.; Yanagawa, R.; Homma, J.Y.; Abe, C.; Morihara, K.; Goda, A.; Takeuchi, S.; Ishihara, T.
Japanese Journal of Experimental Medicine 49(3): 199-207
1979
ISSN/ISBN: 0021-5031 PMID: 114699 Document Number: 153242
An attempt to prevent further outbreaks of haemorrhagic pneumonia in mink due to P. aeruginosa was made in the course of epidemics with injection of the multicomponent vaccine consisting of common protective antigen (OEP) of P. aeruginosa mixed with toxoids of protease and elastase of the bacillus. Outbreaks of haemorrhagic pneumonia, due to P. aeruginosa serotype 8, occurred from August to October 1977 in a total of 13 sheds of three farms located in northeast Hokkaido, rearing 7 452, 2 553 and 10 639 mink, with mortality rates of 11.8%, 13% and 1%, respectively. Vaccination was performed on the three farms 5, 8 and 21 days after the onset of the disease. Inoculation of each mink with 200 mu g or 100 mu g of each of the three components of the multicomponent vaccine was effective in most animals. The period required for revealing the effect of the vaccination was very short, in some cases only a few days. Administration of the vaccine 21 days after the onset of the outbreak was also effective.