Chronic active or aggressive hepatitis and liver cirrhosis with copper accumulation in a Dobermann. Case report
Röcken, F.E.; Nothelfer, H.B.; Janssen, G.
Tierarztliche Praxis 19(6): 675-681
1991
ISSN/ISBN: 0303-6286 PMID: 1796472 Document Number: 385889
Clinical signs, haematological and biochemical abnormalities as well as the pathomorphological and electronmicroscopic findings observed in a 7 1/2 year old spayed female Dobermann suffering from chronic active hepatitis and cirrhosis are described. During almost the whole period of observation the clinical signs were nonspecific. The laboratory findings indicated a progressive liver disease. Gross findings revealed an atrophic cirrhosis. Histopathologically characteristic features of chronic active hepatitis were also seen together with a moderate copper accumulation localized in the periphery of the hepatic lobules. There was no evidence of cholestasis.