Effect of altitude hypoxia on ultrastructure of the left ventricle of rabbit heart and the response of the myocardium to acute verapamil administration at different altitudes
Frolov, V.A.; Matyev, E.S.; Pukhlianko, V.P.; Mambetsadykov, M.B.
Patologicheskaia Fiziologiia i Eksperimental'naia Terapiia 5: 6-9
1991
ISSN/ISBN: 0031-2991 PMID: 1806899 Document Number: 385711
It was shown in experiments on intact male rabbits that moderate-altitude hypoxia causes over-stress of the cardiomyocyte energy-producing apparatus in unadapted animals. Acute infusion of verapamil leads to a high mortality rate among these animals, whereas among aborigines of moderate and low altitudes as well as among animals living in the planes mortality in acute verapamil infusion does not exceed 30%.