Vasculotropin: a new angiogenic growth factor
Moukadiri, H.; Favard, C.; Praloran, V.; Plouet, J.
Pathologie-Biologie 39(2): 153-156
1991
ISSN/ISBN: 0369-8114 PMID: 2017341 Document Number: 385456
A new growth factor, provisionally named vasculotropin (VAS), with a unique specificity for vascular endothelial cells has been purified to homogeneity. VAS is a 45 kDa glycosylated homodimeric protein. Cloning of the VAS gene has evidenced a sequence homology with A and B chains of Platelet-Derived Growth Factor. The receptor on vascular endothelial cells has been shown to be a 180 kDa protein. A 110 kDa receptor has been found on cells that do not respond to the mitogenic effect of vasculotropin, such as lens epithelial cells or corneal endothelial cells.
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