Parameters for the formulation of physical-technical characteristics of granules of theophylline obtained by extrusion-spheronization
Bataille, B.; Rahman, L.; Jacob, M.
Pharmaceutica Acta Helvetiae 66(8): 233-236
1991
ISSN/ISBN: 0031-6865 PMID: 1758901 Document Number: 385255
Spheroids are prepared from microcrystalline cellulose in binary and compound combination with lactose and theophylline, in certain fixed conditions of extrusion and of spheronisation. The present work envisages the influence of combinated raw materials upon the physical-technique characteristic of the made spheroids. Besides a variation in the granulometric distribution a statical study through analysis of variance brings to the fore that the parameters of formulation contribute to modify the properties of hardness and of friability of the minigranules.