Bioavailability of sustained-release theophylline granules in apple sauce in pediatric asthmatic patients
Lotner, G.Z.; Vanderpool, G.E.; Carroll, S.; Tinkelman, D.G.; Spangler, D.L.
Annals of Allergy 50(1): 27-29
1983
ISSN/ISBN: 0003-4738 PMID: 6849516 Document Number: 199671
To facilitate administration of sustained-release theophylline in pediatric patients fourteen children with asthma were studied using intact capsules versus the granular contents in apple sauce. In a cross-over study during multiple dose intervals the effectiveness of this administration technique was demonstrated for maintaining bioavailability and sustained-release characteristics.