Bioavailability of metoclopramide in a sustained-release preparation
Berner, G.; Leuschner, F.; Wagener, H.H.; Becker, A.
Arzneimittel-Forschung 34(5): 637-639
1984
ISSN/ISBN: 0004-4172 PMID: 6540582 Document Number: 222924
The aim of this study was to examine the pharmacokinetical behaviour of metoclopramide of Gastronetron retard capsules after a single administration to 8 healthy male volunteers. Determinations of the concentration of metoclopramide in the serum were made up to 24 h p.a. The calculation of the serum concentration curves was based on an open 2-compartment model. It has been proved that already 30 min after oral administration effective serum concentrations could be reached, which are maintained over about 24 h. An approximate value of 71% was obtained for the bioavailability of metoclopramide of Gastronerton retard capsules. The action achieved by the administration of 1 capsule Gastronerton retard per day can be considered equal to that of 3 single administrations of the conventional oral pharmaceutical form.