The preparation of highly purified insulin and its clinical use. Insulin Cooperative Study Group
Yang, J.; Fang, F.; Zhu, X.; Deng, S.; Zhou, W.; Xing, Z.
Hua Xi Yi Ke da Xue Xue Bao 22(2): 178-180
1991
ISSN/ISBN: 0257-7712 PMID: 1786955 Document Number: 385190
Antigenicity of insulin preparations is obviously related to their purity. The average contents of proinsulin, glucagon and pancreatic polypeptide in highly purified insulin (HP-I) produced by us are 76.0, 2.11 and 0.11 ppm respectively. These results are superior to those for domestic conventional crystalline insulin and single peak insulin (SP-I). The antibodies to insulin, proinsulin and pancreatic polypeptide in serum were examined in 24 diabetic patients treated with HP-I for more than 6 months. The positive rates for the above three antibodies were 37.5%, 0% and 0% respectively. The results showed that the antigenicity of HP-I was much lower than that of domestic conventional crystalline insulin and almost the same as that of MC-I from Nordisk, Denmark.