Clinical trial of malaria prophylaxis in tropical splenomegaly syndrome
Stuiver, P.C.; Ziegler, J.L.; Wood, J.B.; Morrow, R.H.; Hutt, M.S.
British Medical Journal 1(5746): 426-429
1971
ISSN/ISBN: 0026-3656 PMID: 4925506 Document Number: 38458
A controlled, randomized, double-blind trial of malaria prophylaxis in tropical splenomegaly syndrome showed a significant reduction in spleen size and an improvement of anaemia and symptoms in patients treated with antimalarials compared with control subjects receiving placebo. This study confirms the observations from West Africa and provides further indirect evidence for a malarial aetiology of tropical splenomegaly syndrome.