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Biochemistry of methionine sulfoxide residues in proteins

Brot, N.; Weissbach, H.

Biofactors 3(2): 91-96

1991

ISSN/ISBN: 0951-6433
PMID: 1910456
Document Number: 384236
The oxidation of methionine to methionine sulfoxide constitutes one of the many post-translational modifications that proteins undergo. This non-enzymatic reaction has been shown to occur both in vivo and in vitro, and has been associated with the loss of biological activity in a wide variety of proteins and peptides. The presence of methionine sulfoxide residues in proteins is implicated in a variety of pathological conditions. An enzyme that is present in all organisms tested specifically catalyzes the reduction of the methionine sulfoxide residues in proteins. The physiological reductant for this enzyme appears to be thioredoxin.

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Pennington, M.W.; Byrnes, M.E. 1995: Evaluation of TiCl4-mediated reduction of methionine sulfoxide in peptides with oxidizable or reducible residues Peptide Research 8(1): 39-43
Bruskov, V.I.; Bushuev, V.N. 1977: Study by the proton magnetic resonance method of complex formation between nucleosides and compounds modeling amino acid residues of proteins in dimethyl sulfoxide Biofizika 22(1): 26-31
Iakunitskaia, L.M.; Ermolaeva, O.M.; Samartsev, M.A.; Kulikov, S.V. 1993: Use of arylsulfenylchlorides for cleaving fibrinogen at methionine residues Bioorganicheskaia Khimiia 19(3): 373-375
Pauliková, I.; Helia, O. 1994: Sulfoxide reduction: influence of inhibitors and inductors on catalytic activity of sulfoxide reductase in rat liver cytoplasm Die Pharmazie 49(9): 690-691
Fries, E.; Ahlström, E.; Jonasson, I.; Persson, R. 1988: Labelling of proteins with [35S]methionine in monolayer cultures of rat hepatocytes Biochemistry International 16(4): 737-745
Holt, J.C.; Niewiarowski, S. 1985: Biochemistry of alpha granule proteins Seminars in Hematology 22(2): 151-163
Kinoshita, T. 2014: Biochemistry of glycosylphosphatidylinositol (GPI) anchored proteins Seikagaku. Journal of Japanese Biochemical Society 86(5): 626-636
Kuniskiĭ, D.G. 1980: Effect of methionine and vitamins B12 and B15 on the content and distribution of proteins, glycogen and lipids in the hepatic lobules of chickens Arkhiv Anatomii Gistologii i Embriologii 79(10): 97-101
Vynohradova, P.N.; Danylova, V.M. 2011: Investigation of proteins of nerve tissue and their metabolism at the Palladin Institute of Biochemistry of NAS of Ukraine (1972-1990) Ukrains'kyi Biokhimichnyi Zhurnal 83(6): 116-136
Fujii, N.; Kaji, Y. 2008: Racemization of aspartyl residues of proteins in age-related disease Seikagaku. Journal of Japanese Biochemical Society 80(4): 287-293
Viswanadhan, V.N.; Sundaram, K. 1982: Amino acid residues at conservative sites in proteins Physiological Chemistry and Physics 14(3): 179-181
Uhlig, H.J.; Heitmann, P. 1972: The reaction of ethylchloroformate with proteins. a method for the determination of histidine residues Acta Biologica et Medica Germanica 28(3): 431-435
Royston, B.D.; Bottiglieri, T.; Nunn, J.F. 1989: Short term effect of nitrous oxide on methionine and S-adenosyl methionine concentrations British Journal of Anaesthesia 62(4): 419-424
Glaubitt, D.; Broicher, K. 1976: Radiospirometric studies with L-(14C-methyl)methionine and L-(1-14C)methionine in patients with liver cirrhosis Verhandlungen der Deutschen Gesellschaft für Innere Medizin 82 Pt 1: 292-297
Shtutman, T.M.; Artiukh, V.P.; Biber, A.A.; Chagovets, R.V. 1972: Dynamics of changes in methionine metabolism, glutathione levels and ATP-L-methionine-s-adenosyltransferase activity in the rat liver following a single administration of selenite Voprosy Pitaniia 31(3): 12-17
Hochuli, E.; Döbeli, H.; Schacher, A. 1987: New metal chelate adsorbent selective for proteins and peptides containing neighbouring histidine residues Journal of Chromatography 411: 177-184
Sufrin, J.R.; Coulter, A.W.; Talalay, P. 1979: Structural and conformational analogues of L-methionine as inhibitors of the enzymatic synthesis of S-adenosyl-L-methionine. IV. Further mono-, bi- and tricyclic amino acids Molecular Pharmacology 15(3): 661-677
Hodges, R.S.; Zhou, N.E.; Kay, C.M.; Semchuk, P.D. 1990: Synthetic model proteins: contribution of hydrophobic residues and disulfide bonds to protein stability Peptide Research 3(3): 123-137
Okamoto, Y.; Ninomiya, H.; Tanioka, M.; Sakamoto, A.; Miwa, S.; Masaki, T. 1998: Cysteine residues in the carboxyl terminal domain of the endothelin-B receptor are required for coupling with G-proteins Journal of Cardiovascular Pharmacology 31(Suppl): S230-S232
Kawasaki, T. 1982: Studies on "mannan-binding proteins," mammalian lectin specific for mannose and N-acetylglucosamine residues Seikagaku. Journal of Japanese Biochemical Society 54(9): 1019-1032