The importance of determining trophoblastic beta 1-glycoprotein (TBG) for the early diagnosis and prognosis of placental insufficiency in pregnant women with habitual abortion
Mamedalieva, N.M.; Kalafati, T.I.; Sidel'nikova, V.M.; Sukhikh, G.T.
Akusherstvo i Ginekologiia 11: 21-24
1991
ISSN/ISBN: 0300-9092 PMID: 1814220 Document Number: 382990
Blood serum TBH levels were measured by enzyme immunoassay over the course of pregnancy in 40 women with normal pregnancy (controls) and 80 with a history of habitual abortions. Weekly measurements of TBH concentrations have revealed a significant reduction of its secretion over the entire pregnancy course in women with a history of habitual abortions vs. the controls (p less than 0.05; 0.01). A reduced TBH level starting from the first pregnancy trimester (4-7-fold reduction) and no manifest elevation of its concentration were the signs predicting the formation of primary placental insufficiency; the risk of its development was particularly high if these signs were associated with low placentation, detachment of the chorion, and recurring threatened abortions. A 10-fold and lower decrease of TBH level, its gradual or drastic reduction are the unfavorable signs preceding a spontaneous abortion. Therefore TBH measurements may be regarded as a screening test for the prediction and early diagnosis of developing placental insufficiency in pregnant women with a history of habitual abortions.