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Metabolism of vitamin D3 administered in liposomes in rat liver

Apukhovskaia, L.I.; Khrestovaia, N.L.; Antonenko, L.V.

Ukrainskii Biokhimicheskii Zhurnal 63(5): 89-94

1991

ISSN/ISBN: 0201-8470
PMID: 1664993
Document Number: 382895
Incorporation of [3H]-cholecalciferol into the liver and the rate of its conversion into 25-OH-D are significantly larger after intravenous administration of this vitamin into liposomes than its dissolution in ethanol. The latter may be due to a different distribution of vitamin D3 in the cells of the liver. Incorporation of [3H]-vitamin D3 in reticulocytes suggests that its cells are a locus for storage of vitamin D, from which the latter is transported into hepatocytes where its 25-hydroxylation proceeds.

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