Microdose intrauterine levonorgestrel for contraception
Et Al
Contraception 35(4): 363-380
1987
ISSN/ISBN: 0010-7824 DOI: 10.1016/0010-7824(87)90073-4Document Number: 382274
An intrauterine device (IUD) releasing 2 .mu.g of levonorgestrel per 24 hours compared in a randomized multicentre clinical trial with two copper IUDs-the TCu 220C and the Nova T. The 2 .mu.g levonorgestrel device had statistically significantly higher pregnancy rates (from 390 days of use) and higher expulsion rates (up to 570 days). In addition, the total medical removals and removal for bleeding were significantly higher at all intervals where the data were analysed. Most disturbing was a 6.7 increased relative risk of ectopic pregnancy with the steroid-releasing IUD compared to the combined copper IUD data. It is concluded that the goal of microdose administration of 2 .mu.g levonorgestrel to the uterine cavity does not achieve the objectives of a new and improved IUD device which is safe and effective.