A surface membrane study of human cell lines with different interferon sensitivities
Narovlianskiĭ, A.N.; Amchenkova, A.M.; Alimov, E.G.; Gosteva, V.V.; Klitsunova, N.V.; Khesin, I.E.
Voprosy Virusologii 36(1): 48-53
1991
ISSN/ISBN: 0507-4088 PMID: 1713373 Document Number: 381840
A comparative study of surface membranes of human cell J-96 and J-48 cultures with different sensitivity to alpha/beta interferon (IF). Reduced sensitivity of J-41 cells to IF-alpha/beta was found to be accompanied by a loss of highly specific receptors for IF-alpha, the lack of changes in the cell surface structures upon treatment with IF-alpha/beta, reduced intensity of cell fusion upon successive treatment with IF and polyethylene glycol. The results are discussed in connection with the observed changes in the activity of superoxide dismutase in J-96 and J-41 cell lines after treatment with IF.