Autoantibody against liver cell membrane and killer cell activity in chronic liver diseases
Schnabel, R.; Dalmi, L.; Sipka, S.; Bokor, M.; Malatinszky, G.; Garam, T.
Acta Medica Hungarica 48(1-2): 23-31
1991
ISSN/ISBN: 0236-5286 PMID: 1813854 Document Number: 381730
The aim of our present study was to examine the ADCC reaction against liver cell in various chronic liver diseases on the basis of indirect evidence. Forty-nine liver patients and one hundred and twenty-three healthy controls were examined. Anti-LSP autoantibody was determined on rat liver membrane by using the indirect immunofluorescent method. On the other hand, Killer-cell activity against human erythrocyte target cells was established in the lymphocytes of peripheral blood. Anti-LSP autoantibodies were demonstrated in seven patients and were associated with the high Killer-cell activity in six cases. Specific ADCC reaction to liver cell membrane can be assumed if anti-LSP autoantibody presence is topped with increased Killer-cell activity.