Neuroleptic malignant syndrome associated with clozapine use
Anderson, E.S.; Powers, P.S.
Journal of Clinical Psychiatry 52(3): 102-104
1991
ISSN/ISBN: 0160-6689 PMID: 2005071 Document Number: 381265
Clozapine, an atypical antipsychotic drug, is indicated for severely ill schizophrenic patients refractory to treatment with conventional neuroleptics. One advertised advantage of clozapine is the absence of associated neuroleptic malignant syndrome (NMS). On the basis of a clinical case, the authors question this claim. They are concerned that this potentially fatal condition may be misdiagnosed if physicians are not aware of possible NMS associated with the use of clozapine.