Cyclic variation in rats's uterine fluid phosphatase level after administration of lyndral (17 alpha-ethinyl estradiol)
Dubey, A.K.; Singh, C.K.
Indian Journal of Experimental Biology 29(9): 862-863
1991
ISSN/ISBN: 0019-5189 PMID: 1665477 Document Number: 380664
An oral administration of antifertility drug Lyndral (17.alpha.-ethinyl estradiol) at doses 5 .mu.g/rat/a week for 3 consecutive weeks altered the internal biochemical milieu of uterus, showing a cyclic variation in both acid and alkaline phosphatase of the uterine fluid with high levels being present at proestrus and estrus in control rats. In Lyndral treated rats acid phosphatase showed a tendency to increase in estrus and metestrus rats, whereas alkaline phosphatase increased significantly during proestrus and estrus stages of the cycle. All these altered phosphatase levels in uterine fluid, after Lyndral treatment, gives some insight into the hormonal sensitiveness of these enzymes.