Conversion of bromperidol to reduced bromperidol in human liver
Someya, T.; Inaba, T.; Tyndale, R.F.; Tang, S.W.; Takahashi, S.
Neuropsychopharmacology Official Publication of the American College of Neuropsychopharmacology 5(3): 177-182
1991
ISSN/ISBN: 0893-133X PMID: 1755933 Document Number: 380114
Bromperidol (BRP) is an analog of haloperidol, a potent butyrophenone neuroleptic. Reductive conversion of BRP carbonyl group to reduced bromperidol (RBRP) was confirmed in vitro using human liver. This NADPH-dependent reduction of BRP showed a similar inhibition pattern and Michaelis constants to haloperidol carbonyl reductase.
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