Differential effect of cyclosporine A on respiratory burst by several types of human leukocytic cells
Chiara, M.D.; Foot, A.B.; Sobrino, F.; Jones, O.T.
Biochemistry International 23(6): 1185-1193
1991
ISSN/ISBN: 0158-5231 PMID: 1659423 Document Number: 380113
The effect of cyclosporine on PMA-stimulated superoxide production has been studied on human alveolar macrophages, human neutrophils, cytoplasts and Epstein-Barr-virus-transformed B lymphocytes. Cyclosporine inhibits superoxide production in alveolar macrophages but not in neutrophils and cytoplasts. The respiratory burst of B-lymphocytes was scarcely inhibited by cyclosporine. The activity of NADPH oxidase from macrophages and neutrophils was not directly affected by cyclosporine. These data are considered in relation with the proposed mechanism for cyclosporine action and the stimulation of the respiratory burst.