Electroencephalographic changes associated with bromethalin toxicosis in the dog
Dorman, D.C.; Parker, A.J.; Buck, W.B.
Veterinary and Human Toxicology 33(1): 9-11
1991
ISSN/ISBN: 0145-6296 PMID: 2017873 Document Number: 378261
Electroencephalogram (EEG) recordings were obtained before and during the clinical syndrome induced by a bromethalin rodenticide given to dogs. Nine dogs given 6.25 mg bromethalin/kg po developed clinical signs and EEG abnormalities 15 to 58 h postdosing. Predominant abnormal EEG changes included spike and spike-and-wave EEG patterns (66%), high voltage slow wave (HVSA, 50-150 microV, 1-6 Hz) activity (44%) photoconvulsive or photoparoxysmal irritative responses (44%), and marked voltage depression (dominant activity less than 10 microV) in all leads (33%).