No evidence for HTLV-I infection in 24 cases of French and Portuguese mycosis fungoïdes and Sezary syndrome (as seen in France)
Capésius, C.; Saal, F.; Maero, E.; Bazarbachi, A.; Lasneret, J.; Laroche, L.; Gessain, A.; Hojman, F.; Périés, J.
Leukemia 5(5): 416-419
1991
ISSN/ISBN: 0887-6924 PMID: 2033961 Document Number: 377925
A survey in search of evidence for HTLV-1 infection was conducted on French and Portuguese patients residing in France and a diagnosis of mycosis fungoides or Sezary syndrome. Methods used in this investigation included serological assays (ELISA, Western blot, particle agglutination, indirect immunofluorescence) and DNA molecular studies (Southern blot and polymerase chain reaction). Cultures of peripheral blood mononuclear cells were performed and checked by electron microscopy and reverse transcriptase assay. The results indicate that neither HTLV-1 nor a closely related retrovirus are associated with mycosis fungoide or Sezary syndrome in the cases studied.