Antiulcerogenic (therapeutic and preventive) properties of a phenylalkyl syndonimine psychostimulant
Samonina, G.E.; Natsvlishvili, N.A.; Ashmarin, I.P.
Voprosy Meditsinskoi Khimii 37(6): 72-73
1991
ISSN/ISBN: 0042-8809 PMID: 1812618 Document Number: 376708
Intragastric administration of 96% ethanol, 1 ml/100 g of body mass, induced ulcerous impairments of rat gastric mucosal membrane, which were marked within 8 min after ethanol administration and reached the maximal size within 3 hrs. Psychostimulants of the phenylalkyl sydnonimime series OF 743, administered after the ethanol treatment, decreased distinctly the ethanol-induced impairments of gastric mucosal membrane and this effect was higher in simultaneous inoculation of the drug and ethanol. The data obtained suggest that preparation OF 743 exhibited both protective and curative antiulcerogenic efficiency.