Results of using tricyclic antidepressive drugs in the treatment of endogenous depression (comparative analysis of 7 drugs)
Beresewicz, M.; Bidzińska, E.; Koszewska, I.; Puzyński, S.
Psychiatria Polska 25(3-4): 13-18
1991
ISSN/ISBN: 0033-2674 PMID: 1687987 Document Number: 376521
A group of 250 patients with endogenous depression was studied. Amitriptyline proved to be the most effective drug (51% positive responses) followed by noxiptilin (50%), imipramine (42%), dibenzepin (43%). Clomipramine, desipramine, and nomifensine appeared to be the least effective. Demographic or clinical factors such as age, sex, type of affective illness, severity of depressive syndrome or its particular symptoms (depression, fear, anxiety, psychomotor impairment or biological rhythm alteration) did not show any potential for prediction of the treatment outcome. Worse therapeutic results were observed in patients who had already been given antidepressant treatment for the current depressive cycle before the assessment.