Interaction of dexamethasone with phenytoin
Lackner, T.E.
PharmacoTherapy 11(4): 344-347
1991
ISSN/ISBN: 0277-0008 PMID: 1923918 Document Number: 375906
Phenytoin and dexamethasone are frequently administered concurrently to prevent consequences of central nervous system pathology. Limited and conflicting data are available regarding an interaction between the agents. A patient receiving dexamethasone required a daily phenytoin dose of greater than 10 mg/kg to maintain the phenytoin serum concentration within the usual therapeutic range. The concentration increased by nearly 300% after dexamethasone was discontinued.
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