Therapy of peripheral arterial occlusive disease with special reference to prostaglandins
Creutzig, A.
Zeitschrift für die Gesamte Innere Medizin und ihre Grenzgebiete 46(3): 59-67
1991
ISSN/ISBN: 0044-2542 PMID: 1828125 Document Number: 375572
Therapy of chronic arterial occlusive disease primarily includes evaluation and treatment of risk factors as prophylaxis for preventing progression of arteriosclerosis. When patients suffer from claudication walking exercise is the therapy of choice. Only in cases with severe claudication (walking distance under 100 m) and rest pain or ischemic ulcers reopening procedures are necessary. Bypass surgery is supported by the different transluminal angioplasty techniques, which are suited even for older and multimorbid patients. A pharmacological treatment of peripheral arterial occlusive disease should be introduced only for preventing progression of the disease or re-occlusions following surgery or angioplasty or in those cases in whom reopening techniques are not possible or not successful. Here prostaglandin E1 has been proven to be effective in many clinical trials. The combination of surgery, angioplasty and pharmacological treatment allows to avoid major amputations in most patients with critical limb ischemia.