Polymer-drug complexes in the treatment of extensive ovarian cancer
Novikova, E.G.; Borisov, V.I.; Dmitriev, D.G.; Zel'vin, B.M.; Karseladze, A.I.; Shchitkov, K.G.; Li, A.D.
Sovetskaia Meditsina 11: 27-29
1991
ISSN/ISBN: 0038-5077 PMID: 1767307 Document Number: 375208
The paper presents the results of intracavitary chemotherapy with deposited cytostatics of advanced ovarian cancer as well experimental, morphological, biochemical and pharmacological data. Intraabdominal introduction of microspheres filled with cyclophosphamide, 5-fluorouracil, doxorubicin can be a variant of drug therapy in multimodality treatment of ovarian cancer. Combination of intracavitary chemotherapy with a systemic one has the advantage of local and regional effect which is not inhibited by mediated action of the deposited cytostatics via the systemic blood flow. The method is indicated in residual tumor dissemination after cytoreductive surgery and ovarian cancer with ascites.