Adult Gaucher's disease with pulmonary involvement
Jarnvig, I.L.; Milman, N.; Jacobsen, G.K.; Kassis, E.
Ugeskrift for Laeger 153(40): 2832-2834
1991
ISSN/ISBN: 0041-5782 PMID: 1926620 Document Number: 3752
Gaucher's disease is an autosomal recessive disorder caused by deficiency of the enzyme glucocerebrosidase with accumulation of glucocerebroside in the reticuloendothelial system. Affection of the lungs by this disease is extremely rare. When Gaucher cells infiltrate the lung, fibrosis may result. We describe a case with adult type Gaucher's disease who, besides affection of liver, spleen and bone marrow, had severe pulmonary involvement with extensive interstitial fibrosis, increased pulmonary vascular resistance, and pronounced reduction in diffusion capacity.
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