Top Abstract Purchase Related
Home
>
Node
>
Subnode

Studies on 5-FU concentration in serum and prostate cancer tissue after oral administration of UFT

Shinoda, I.; Takahashi, Y.; Takeuchi, T.; Kuriyama, M.; Ban, Y.; Kawada, Y.; Ito, Y.; Yamamoto, N.; Maeda, S.; Tada, K.

Hinyokika Kiyo. Acta Urologica Japonica 37(7): 711-715

1991

ISSN/ISBN: 0018-1994
PMID: 1927771
Document Number: 374154
The serum, urine and tissue concentrations of 1-(2-tetrahydrofuryl)-5-fluorouracil (FT), 5-fluorouracil (5-FU) and uracil were estimated in 11 patients with prostate cancer (4 cases treated by total prostatectomy and 7 cases by transurethral resection (TUR-P) after oral administration of UFT. The concentration of FT, 5-FU and uracil in the tumor tissue (micrograms/g) were 5.920 +/- 5.902, 0.018 +/- 0.012 (T/S; 2.20) and 7.785 +/- 4.151 in 4 patients treated by total prostatectomy and 1.943 +/- 1.355, 0.024 +/- 0.010 (T/S; 1.46) and 4.616 +/- 2.848 in 7 patients treated by transurethral resection of prostate. The concentrations of FT, 5-FU and uracil in the tumor tissue did not increase as compared with those in normal tissue in 4 cases treated by total prostatectomy.

Document emailed within 1 workday
Secure & encrypted payments

Degen, J.; Ringwelski, L.; Maier-Lenz, H. 1983: Concentration of cefadroxil in kidney tissue and serum after oral administration in patients with normal and impaired renal function Arzneimittel-Forschung 33(9): 1339-1342
Fukunaga, H.; Katsumi, M.; Aoki, Y.; Oka, S.; Konishi, R.; Yukawa, H.; Kawaguchi, T.; Tamaki, Y.; Takifuji, K. 1987: 5-FU concentration in tumor tissue and the antitumor effect in patients with gastric cancer after oral administration of UFT Gan to Kagaku Ryoho. Cancer and ChemoTherapy 14(9): 2735-2739
Shimoyama, T.; Shimizu, T.; Kusano, H.; Ishikawa, H.; Miyashita, K.; Nakazaki, T.; Yasutake, T.; Yoshida, A.; Yoshida, K.; Ogawa, T. 1993: Studies on tissue concentration of tegafur, 5-fluorouracil, uracil after UFT administration together with the study of microangiography of colorectal cancer Gan to Kagaku Ryoho. Cancer and ChemoTherapy 20(1): 125-130
Shohat, J.; Molcho, M.; Glazer, I.; Halkin, H. 1979: Serum concentration of aminophylline after rectal, oral and intravenous administration Harefuah 96(11): 622-624
Sadowski, Z.; Tubylewicz, H. 1974: Serum oxacillin concentration and urinary excretion following oral administration Polski Tygodnik Lekarski 29(9): 355-357
Inoue, S.; Shibata, S.; Okumura, A.; Tanaka, T.; Onitsuka, Y.; Yoshimura, T.; Aiko, A.; Ikuta, Y.; Fukuma, K.; Matsuura, K. 1985: UFT concentration in serum and tissues of patients with gynecologic malignant tumors following oral administration Gan to Kagaku Ryoho. Cancer and ChemoTherapy 12(3 Part 1): 499-504
Liashenko, I.I. 1973: The concentration of penicillin in the serum and palatine tonsil tissue of healthy subjects and angina patients following intramuscular administration of the preparation Antibiotiki 18(11): 1046-1049
Suemasu, K.; Nomoto, C.; Higashi, Y. 1982: Concentration of 5-FU level in the tissue and blood of the patients with breast cancer by preoperative administration of UFT Gan to Kagaku Ryoho. Cancer and ChemoTherapy 9(4): 667-671
Koja, S.; Itokazu, T.; Kamiya, S.; Maeshiro, N.; Yamauchi, M.; Esu, H.; Simoji, Y.; Kanazawa, T.; Noda, Y. 1994: Tissue concentration of tegafur suppository in patients with head and neck cancer--concentration of 5-FU in cancer tissue Gan to Kagaku Ryoho. Cancer and ChemoTherapy 21(7): 981-985
Suzuki, M.; Sekiguchi, I.; Ohwada, M.; Tamada, T. 1985: Level of 5-FU in uterine cervical cancer tissue after oral administration of UFT Gan to Kagaku Ryoho. Cancer and ChemoTherapy 12(11): 2139-2144
Janczewska, I.; Bartnik, W.; Butruk, E.; Ostrowski, J. 1988: Serum vitamin a and e after their oral administration in cancer patients Rivista Europea Per le Scienze Mediche e Farmacologiche 10(6): 473-477
Romppanen, J.; Haapalainen, T.; Punnonen, K.; Penttilä, I. 2002: Serum sialic acid and prostate-specific antigen in differential diagnosis of benign prostate hyperplasia and prostate cancer Anticancer Research 22(1a): 415-420
Rabast, U.; Kasper, H.; Schönborn, J.; Knechtel, B. 1977: Blood glucose concentration and insulin activity in serum after administration of the beta receptor blockader nifenalol-HC1 (INPEA). Studies in metabolically healthy people and diabetics Therapie der Gegenwart 116(6): 1162-1174
Kilchling, H. 1975: Comparative studies of oral "quick-release" and "slowrelease" iron preparations in the postabsorption serum iron concentration test Arzneimittel-Forschung 25(1): 105-110
Amayo, A.; Obara, W. 2004: Serum prostate specific antigen levels in men with benign prostatic hyperplasia and cancer of prostate East African Medical Journal 81(1): 22-26
Miyamoto, S.; Jimbo, H.; Totsuka, Y.; Mashimo, T.; Umeyama, T.; Uehara, H.; Shinozaki, T. 1995: Change in serum prostate specific antigen values in men who had no evidence of prostate cancer on initial biopsy Hinyokika Kiyo. Acta Urologica Japonica 41(10): 767-770
Liang, J.; Zhao, X.-Z.; Shi, J.-Y.; Qiu, X.-F.; Zhang, Q.; Zhuang, J.-L.; Wang, W.; Deng, Y.-M.; Huang, H.-F.; Zhang, C.-W.; Guo, H.-Q. 2019: Combination of serum PSA assay, multi-parametric MRi and targeted prostate biopsy for prostate cancer screening in Nanjing Zhonghua Nan Ke Xue 25(9): 815-822
Yamaguchi, K.; Tanaka, M.; Kitagawa, N.; Kotake, T.; Yanagi, S.; Ito, H. 1989: The significance of serum prostate-specific antigen, gamma-seminoprotein and prostatic acid phosphatase as prostate cancer markers Hinyokika Kiyo. Acta Urologica Japonica 35(6): 987-991
Rahardjo, D.; Kamil, S.T.; Pakasi, L.S. 2000: Rationale for using serum prostate-specific antigen (PSA) level and PSA density (PSAD) to detect prostatic malignancy in a country with low prostate cancer incidence Gan to Kagaku Ryoho. Cancer and ChemoTherapy 27(Suppl 2): 563-570
Li, X.F. Ye, B.L.; Wu, X.W.; Wu, Z.Y.; Kong, S.M.; Sang, G.W. 1988: Effects of long term use of oral contraceptives on serum prl and the response to oral administration of metoclopramide Advances in Contraception 4(1): 64-65