The behavior of substance P concentration in rat plasma in the acute single- and combined-actions of trichloroethylene and ethanol
Fendius, R.R.; Gutewort, T.; Hinz, G.
Die Pharmazie 46(3): 215-216
1991
ISSN/ISBN: 0031-7144 PMID: 1715586 Document Number: 372800
In experimental studies in male Wistar-rats exerted for determination of trichloroethylene, ethanol and combined action influences on the substance P plasma concentrations. These concentrations were determined by a radioimmunological method. The acute exposure of trichloroethylene and ethanol lead to a significant rise of substance P. We found high substance P concentration peaks, in principle, 4 h after acute exposure and the combined action shows the greatest effect.
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