Cholesterol metabolism in patients with coronary heart disease
Miettinen, T.A.
Annals of Clinical Research 3(6): 313-322
1971
ISSN/ISBN: 0003-4762 PMID: 5156891 Document Number: 37268
Cholesterol metabolism was studied in 3 groups of patients under 50 years old with coronary heart disease by a sterol balance technique with acetate-14C and mevalonate-3H and estimation of serum methyl sterols. Serum lipids were normal in one group, cholesterol alone was raised in the second group and both cholesterol and triglycerides were high in the third group. There were obese and lean patients in each group. Patients with normal serum lipids showed normal or occasionally increased cholesterol production. In the patients with high serum cholesterol, production tended to be subnormal and to correlate negatively with serum cholesterol suggesting that removal was impaired and synthesis slightly depressed. In the other patients there was a negative correlation between serum cholesterol and cholesterol production. Cholestyramine by mouth increased cholesterol excretion as bile acids in hyperglyceridaemic patients less than it did in controls.