Lymphoma of the splenic mantle. Morphologic, immunologic and ultrastructural characterization of a case
Sabater Marco, V.; Alemany Monraval, P.; Ferrando Marco, J.; Salvador Villalba, I.; Martorell Cebollada, M.
Medicina Clinica 96(2): 63-65
1991
ISSN/ISBN: 0025-7753 PMID: 2023478 Document Number: 372618
We present a splenic primary mantle lymphoma in a 64 year old woman, without peripheral lymphoadenopathy and stage IV at the moment of the diagnosis. Grossly a splenic infiltration was observed. Microscopically, a nodular lymphoma of small lymphocytes proliferating around benign germinal centers makes the diagnosis. Immunohistochemically, tumoral lymphocytes expressed SIgG/kappa and CD5 (Leu-1). Markers of follicular center origin CD10 (CALLA) were negative. According to working formulation mantle-cell lymphoma is considered a lymphoma of intermediate grade of malignancy. In our case, the morphologic, immunologic, ultrastructural findings and clinical evolution were more characteristics of a low grade lymphoma that a intermediate grade of malignancy.