Modulation of epidermal growth factor binding to receptor by isoproterenol and cholera toxin in primary cultured hepatocytes
Katoh, S.; Kohno, H.; Ohkubo, Y.
Research Communications in Chemical Pathology and Pharmacology 73(2): 145-152
1991
ISSN/ISBN: 0034-5164 PMID: 1784831 Document Number: 372163
The treatment of rat hepatocytes with isoproterenol induced the increase in the affinity of high affinity binding sites and the decrease in the number of low affinity binding sites of epidermal growth factor (EGF). Similar results were obtained from the pretreatment of hepatocytes with cholera toxin. These results suggest that adenylate cyclase affects the affinity and number of EGF-receptor in the hepatocytes.
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