Fatty acids in erythrocyte membranes and the status of lipid peroxidation in painters
Loseva, M.I.; Shpagina, L.A.; Sharapov, V.I.; Sazonova, O.V.; Grek, O.R.
Gigiena Truda i Professional'nye Zabolevaniya (2): 19-21
1991
ISSN/ISBN: 0016-9919 PMID: 2055538 Document Number: 371488
Spectrographic studies of fat acids in erythrocytic membranes and lipid peroxidation (LPO) contributed to the identification of different phases in the formation of damage effects. Exposition to toxic complexes (mostly solvents) in the first year caused a predominant growth of the antioxidant systems' activity characteristic of the processes of adaptation. In case with the work duration from one to five years, the u saturated fat acid content growth was accompanied by both pro- and antioxidative processes, which was indicative of the compensatory nature of the revealed changes. The most vivid shifts in the LPO reactions and the fat acids' content in erythrocytic membranes were found in the occupational group of patients engaged in the profession for more than 5 years. Those included major changes in the spectrum of both saturated and unsaturated acids, LPO activation with concomitant depression of the antioxidative systems.