The effect of prostaglandin I2 on the postischemic recovery of the transplanted heart under deep hypothermia
Yoshimura, H.; Ohkado, A.; Shida, T.
Nihon Kyobu Geka Gakkai 39(1): 52-58
1991
ISSN/ISBN: 0369-4739 PMID: 2026915 Document Number: 371371
The effect of prostaglandin I2 (PGI2) on the postischemic recovery of the heart orthotopically transplanted under deep hypothermia was evaluated using puppies. Twenty-four pairs of dogs were divided into 4 groups according to the usage of PGI2 and preservation of the donor heart (in Euro-Collins' solution at 4 degrees C for 4 hours), namely Group I (non PGI2, no preservation), Group II (PGI2-treated, no preservation), Group III (non PGI2, 4 hours preservation), Group IV (PGI2-treated, 4 hours preservation). PGI2 was added into the donor's cardioplegic solution (500 ng/ml) and also was given intravenously to the recipient during cooling and rewarming periods (1 microgram/kg/min), and left ventricular pressure, max dp/dt, cardiac output were continuously monitored, and postmortem studies on myocardium were performed. Results were as follows: PGI2 yielded significantly better recovery of cardiac output and left ventricular pressure after transplanted of the heart, [Group I vs Group II (p less than 0.05), Group III vs Group IV (p less than 0.01)]. This effect was especially remarkable in the preserved heart groups. Microscopically, the contraction band formation in the myocardium was more prominent in Group III than in Group IV. It is concluded that PGI2 is of great use for the postischemic recovery of the transplanted heart not only by ameliorating the myocardial ischemic recovery of the transplanted heart, but also by reducing the afterload of the recipient during the recovery period from deep hypothermia.