Effect of Polish antacids on prostaglandin E2 values in gastric mucosa
Mach, T.; Basista, M.; Bogdał, J.; Kostka-Trabka, E.
Polski Tygodnik Lekarski 46(45-47): 892-895
1991
ISSN/ISBN: 0032-3756 PMID: 1669463 Document Number: 371236
An effect of the locally produced antacids on PGE2 in the gastric mucosa has been studied both clinically and experimentally. It was found, that such preparations as Alugastrin, Gastrin, and Vikalin administered chronically to the rats accelerate healing rate of peptic ulcer, decreasing in the same time the PGE2 level in the gastric mucosa. Alugastrin in a single oral dose significantly increased pH of the stomach and did not affect endogenous PGE2 level. Some locally produced antacids exert an effect on endogenous PGE2 production in the gastric mucosa, which could be important for their efficacy.