Prostaglandin E2 binding by gastric mucosa cells in the rat
Deribas, V.I.; Bersimbaev, R.I.; Tairov, M.M.
Arkhiv Anatomii Gistologii i Embriologii 87(9): 62-68
1984
ISSN/ISBN: 0004-1947 PMID: 6594982 Document Number: 236430
After incubation of gastric pieces with [3H] prostaglandin E2 (PGE2) the label is accumulating predominantly over the cells situating in the middle third of the gastric glands proper, where mucus-secreting cells are mainly situated. As demonstrate biochemical experiments, [3H] PGE2 combines 5.5 times as intensively with the isolated cells fraction, which consists mainly of mucocytes but not of parietal cells. A suggestion is made that prostaglandin E2 contributes to biosynthesis and mucus secretion in the stomach when it immediately combines with mucocytes.