Effect of retinoic acid on the infiltration of murine melanoma cells into the type I collagen gel
Kono, T.; Furukawa, M.; Tanii, T.; Taniguchi, S.; Mizuno, N.; Ishii, M.; Hamada, T.
Acta Dermato-Venereologica 71(1): 41-44
1991
ISSN/ISBN: 0001-5555 PMID: 1676213 Document Number: 370705
Two lines of murine melanoma cells (B16 and Cloudman S91) were cultured on type I collagen gel and the effects of all-trans-retinoic acid on the growth and infiltration into the gel were assayed. In both lines, proliferation and the degree of infiltration were suppressed by the addition of all-trans-retinoic acid. The infiltration-inhibiting effect was expressed very rapidly and was dose-dependent at concentrations ranging from 10-7 to 10-5 M of all-trans-retinoic acid. These results suggest the anti-invasive effects of all-trans-retinoic acid on melanoma cells.