Changes in adenosine deaminase and antioxidative enzyme activity in patients with lung diseases of dust etiology
Nemechek, I.B.; Lur'e, B.L.; Velichkovskiĭ, B.T.
Biulleten' Eksperimental'noi Biologii i Meditsiny 112(7): 53-55
1991
ISSN/ISBN: 0365-9615 PMID: 1793856 Document Number: 368399
Activity of purine metabolism enzyme, adenosine deaminase (ADA) in lymphocytes and erythrocytes from patients with pneumoconiosis and chronic bronchitis was determined. ADA activity decrease was found in lymphocytes and erythrocytes for both decreases. The observed decrease of ADA activity indicates that after the long term work in mineral dust industry damage of purine metabolism takes place, that is similar to the disturbance observed under secondary immunodeficiency. Changes in activity of superoxide dismutase and catalase show some decrease of functional activity of anti-radical protection. Therefore the results obtained can be used for the selection of a group with highest risk of predisposition to these diseases.