Acute non-lymphocytic leukemia following FAM combination adjuvant chemotherapy for gastric and lung adenocarcinoma
Bouillet, T.; Lepage, E.; Gisselbrecht, C.; Boiron, M.
Nouvelle Revue Francaise d'Hematologie 32(3): 207-209
1990
ISSN/ISBN: 0029-4810 PMID: 2120675 Document Number: 367543
We report 2 cases of acute non-lymphocytic leukemia with distinct clinical and karyotypic features shared by therapy-related acute non-lymphocytic leukemia occurring after adjuvant chemotherapy including 5-fluorouracil, doxorubicin and mitomycin C. Our observation suggests a causal relationship between exposure to mitomycin C and the occurrence of acute non-lymphocytic leukemia.
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