A case of Waldenström macroglobulinemia terminating in acute lymphoblastic leukemia
Angelopoulos, N.; Camerone, G.; Guzzini, F.; Polli, N.
Haematologica 74(3): 309-312
1989
ISSN/ISBN: 0390-6078 PMID: 2511104 Document Number: 3673
A case of acute lymphoblastic leukemia occurring in a patient with Waldenström macroglobulinemia more than 6 years after the onset of the disease is reported. At the time of acute transformation, bone marrow and peripheral blood lymphoid populations were almost entirely represented by lymphoblasts; the serum monoclonal peak had disappeared and no cells bearing surface or intracytoplasmic immunoglobulins were found. This observation suggests that the blast crisis might be derived from a dedifferentiative process within the lymphatic clone of the chronic phase.
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