Methotrexate induced pulmonary disease
Sundset, A.; Ellingsen, I.; Bergholtz, B.
Tidsskrift for den Norske Laegeforening Tidsskrift for Praktisk Medicin Ny Raekke 110(28): 3612-3614
1990
ISSN/ISBN: 0029-2001 PMID: 2260058 Document Number: 367185
Methotrexate may cause pulmonary side effects. Two cases of methotrexate-induced fibrosing alveolitis are reported. One of the patients died from perforated gastric ulcer, the other was successfully treated with systemic steroids. The pulmonary side effects of methotrexate are reviewed. The most common clinical manifestation is fibrosing alveolitis. Pulmonary fibrosis and acute, non-cardiogenic pulmonary oedema are rare.