Changes of rabbit pulmonary elastic properties and bronchomotricity in experimentally induced chronic Chagas' disease
Tavares, P.; Saldiva, P.H.; Caldeira, M.P.; Calheiros, D.F.; Gouveia, M.A.; Saldiva, C.D.
Revista do Instituto de Medicina Tropical de Sao Paulo 28(5): 325-329
1986
ISSN/ISBN: 0036-4665 PMID: 3108999 Document Number: 279224
In order to study the role of bronchial denervation of Chagas' disease, the mechanical properties and the bronchomotricity of 6 chronic chagasic and 4 control rabbits were investigated. The wholebody plethysmography method was used and the measurements were performed before and after intravenous administration of histamine chlorydrate (0.11 mg/kg body weight). A smaller increase of the functional residual capacity, an almost unchanged peak passive expiratory flow after the histamine administration and a shift to the right of the static transpulmonary pressure/volume curve observed in the chagasic animals indicating an alteration of the bronchial tree, mainly consisting of a decreased bronchoreactivity.