Bombesin, dermorphin, physalaemin and sauvagine: effects on superficial and depth EEG tracings in epileptic and non-epileptic rats

De Romanis, F.; Sopranzi, N.

La Clinica Terapeutica 133(1): 35-38

1990


ISSN/ISBN: 0009-9074
PMID: 1971781
Document Number: 366849
The effects of bombesin, sauvagine, physalaemin and dermorphin on rat CNS were observed. These peptides were administered to non-epileptic and epileptic rats: SEEG and DEEG were recorded. On the normal electrical background activity of rat brain only physalaemin had no effect. All the other peptides gave rise to slow activity with different duration. In the epileptic rat only sauvagine showed no effect whilst physalaemin reduced the epileptic activity, bombesin seemed to strengthen the action of metrazol and dermorphin blocked it at the onset. These observations will undergo FFT (Fast Fourier Transform) analysis.

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