MHC class i antigen expression and alterations induced by rIFN gamma in tumor hybrid cell immunogenicity
Goguel, A.F.; Le Borgne, F.; Baude, B.; Canavate, M.L.; Tlouzeau, S.; Derhy, M.L.; Lespinats, G.
In Vivo 4(3): 185-190
1990
ISSN/ISBN: 0258-851X PMID: 2133261 Document Number: 365473
Hybridization of a poorly immunogenic tumor cell with an allogeneic cell was performed in order to improve tumor immune response; several variants derived from one hybrid tumor cell were studied. We compared the immunogenicity of these variants and their allogeneic and syngeneic class I antigen expression before and after IFN gamma treatment. Allogeneic class I antigens were weakly expressed in all variants; IFN treatment enhanced their expression similarly in both immunogenic and nonimmunogenic variants. Syngeneic class I antigen expression differed among variants: IFN treatment induced changes in their expression which corresponded to a posttranscriptional event and which could, at least partly, explain the modifications observed in their immunogenicity.