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Variation of MHC class i and Ii antigen expression in relation to lymphocytic infiltrates and interferon-gamma positive cells

Hedfors, E.; Lindahl, G.

Journal of Rheumatology 17(6): 743-750

1990

ISSN/ISBN: 0315-162X
PMID: 2117658
Document Number: 349509
The occurrence of MHC antigens on epithelial cells in lip salivary glands obtained from patients with various connective tissue diseases and from bone marrow recipients was studied. The amount of infiltrating lymphocytes correlated to an increase in MHC class I and II antigen expression, but not to diagnosis or glandular function. Interferon-gamma + infiltrating cells were scanty. The role of interferon-gamma as the main inducer of MHC antigens and the notion "aberrant" HLA-DR thought to perpetuate chronic autoimmune disease are questioned.

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Kalovidouris, A.E. 1992: The role of cytokines in polymyositis: interferon-gamma induces class Ii and enhances class i major histocompatibility complex antigen expression on cultured human muscle cells Journal of Laboratory and Clinical Medicine 120(2): 244-251
Xiang, J.; Moyana, T. 1998: Cytotoxic CD4+ T cells associated with the expression of major histocompatibility complex class II antigen of mouse myeloma cells secreting interferon-gamma are cytolytic in vitro and tumoricidal in vivo Cancer Gene Therapy 5(5): 313-320
Takemura, Y.; Koide, Y.; Kawabata, M.; Kitajima, S.; Ohba, C.; Suzuki, H.; Sekiguchi, S. 1989: Synergistic enhancement of class i major histocompatibility complex antigen expression in K562 cells induced by recombinant human interferon-gamma and tumor necrosis factor in combination Experimental Hematology 17(7): 795-799
Inoue, M.; Okumura, M.; Miyoshi, S.; Shiono, H.; Fukuhara, K.; Kadota, Y.; Shirakura, R.; Matsuda, H. 1999: Impaired expression of MHC class II molecules in response to interferon-gamma (IFN-gamma) on human thymoma neoplastic epithelial cells Clinical and Experimental Immunology 117(1): 1-7
Geppert, T.D.; Lipsky, P.E. 1985: Antigen presentation by interferon-gamma-treated endothelial cells and fibroblasts: differential ability to function as antigen-presenting cells despite comparable Ia expression Journal of Immunology 135(6): 3750-3762
Green, W.R.; Phillips, J.D. 1986: Differential induction of H-2K vs H-2D class i major histocompatibility complex antigen expression by murine recombinant interferon-gamma Journal of Immunology 137(3): 814-818
Garson, D.; Dokhélar, M.C.; Wakasugi, H.; Mishal, Z.; Tursz, T. 1985: HLA class-i and class-Ii antigen expression by human leukemic K562 cells and by Burkitt-K562 hybrids: modulation by differentiation inducers and interferon Experimental Hematology 13(9): 885-890
Walsh, L.J.; Parry, A.; Scholes, A.; Seymour, G.J. 1987: Modulation of CD4 antigen expression on human gingival Langerhans cells by gamma interferon Clinical and Experimental Immunology 70(2): 379-385
Esumi, N.; Hunt, B.; Itaya, T.; Frost, P. 1991: Reduced tumorigenicity of murine tumor cells secreting gamma-interferon is due to nonspecific host responses and is unrelated to class i major histocompatibility complex expression Cancer Research 51(4): 1185-1189
Lahat, N.; Sobel, E.; Kraiem, Z. 1993: Control of HLA-DR antigen expression by gamma-interferon: separate signal transduction mechanisms in malignant and nonmalignant human thyroid cells Cancer Research 53(17): 3943-3947
Hanaumi, K.; Gray, P.; Suzuki, T. 1984: Fc gamma receptor-mediated suppression of gamma-interferon-induced Ia antigen expression on a murine macrophage-like cell line (P338D1) Journal of Immunology 133(6): 2852-2856
Nakagawa, T.; Nakagawa, N.; Volkman, D.J.; Fauci, A.S. 1986: Sequential synergistic effect of interleukin 2 and interferon-gamma on the differentiation of a Tac-antigen-positive B cell line Journal of Immunology 136(1): 164-168
Charreau, B.; Coupel, S.; Boulday, G.; Soulillou, J.P. 2000: Cyclosporine inhibits class II major histocompatibility antigen presentation by xenogeneic endothelial cells to human T lymphocytes by altering expression of the class II transcriptional activator gene Transplantation 70(2): 354-361
Lu, Y.; Boss, J.M.; Hu, S.X.; Xu, H.J.; Blanck, G. 1996: Apoptosis-independent retinoblastoma protein rescue of HLA class Ii messenger RNA IFN-gamma inducibility in non-small cell lung carcinoma cells. Lack of surface class Ii expression associated with a specific defect in HLA-DRA induction Journal of Immunology 156(7): 2495-2502
Goguel, A.F.; Le Borgne, F.; Baude, B.; Canavate, M.L.; Tlouzeau, S.; Derhy, M.L.; Lespinats, G. 1990: MHC class i antigen expression and alterations induced by rIFN gamma in tumor hybrid cell immunogenicity In Vivo 4(3): 185-190
Tamiolakis, D.; Venizelos, I. 2006: Inverse correlation between HLA-DR antigen expression and CD4 positive lymphocytic populations in normal mucosa, tubulovillous adenoma, and invasive carcinoma of the colon Ceskoslovenska Patologie 42(2): 52-58
Ijzermans, J.N.; Bouwman, E.; Jeekel, J.; Marquet, R.L. 1990: Donor pretreatment with IFN-gamma enhances MHC class Ii antigen expression and accelerates graft rejection by modified recipients Transplantation Proceedings 22(4): 1941-1942
Udaka, K.; Marusić-Galesić, S.; Walden, P. 1994: CD4+ and CD8+ alpha beta, and gamma delta T cells are cytotoxic effector cells of beta 2-microglobulin-deficient mice against cells having normal MHC class i expression Journal of Immunology 153(6): 2843-2850
Rubenstein, M.; Hollowell, C.M.P.; Guinan, P. 2011: Bispecific oligonucleotides may induce interferon expression in LNCaP cells enhancing surface antigen expression: effect of intrastrand base pair complementarity In Vivo 25(1): 61-67
Caporali, R.; Epis, O.; Negrini, R.; Scirè, C.A.; Solcia, E.; Montecucco, C. 2003: Salivary gland lymphocytic infiltrates and Helicobacter pylori serology in anti-SSA/Ro positive patients in Italy Clinical and Experimental Rheumatology 21(2): 266-267