Pharmacokinetic study with synthetic salmon calcitonin (Sandoz)
Beveridge, T.; Niederer, W.; Nüesch, E.; Petrin, A.
Zeitschrift für Gastroenterologie. Verhandlungsband 10: 12-15
1976
ISSN/ISBN: 0172-8504 PMID: 64046 Document Number: 3654
18 patients randomly divided into 3 groups of six each received 35 mug (140 M.R.C. Units) of synthetic salmon calcitonin intravenously, intramuscularly or subcutaneously. Plasma and urin concentrations were determined using the radioimmunoassay method. There was a rapid distribution phase of ca. 12 minutes after intravenous injection then an elimination half-life of 1.1 hours. The volume of distribution was 11 litres. The invasion half-life after intramuscular and subcutaneous administration was 12 and 11 minutes respectively and the elimination half-lives 1 and 1.5 hours, respectively. The bioavailability of the intramuscular and subcutaneous forms was found to be 66 and 71% respectively when areas under their plasma concentration/time curves were compared with the intravenous area.
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