Clinical significance of nocturnal blood pressure and blood pressure variability: analysis of 522 cases
Palatini, P.; Mormino, P.; Martina, S.; Businaro, R.; Penzo, M.; Racioppa, A.; Guzzardi, G.; Anaclerio, M.; Pessina, A.C.
Cardiologia 35(3): 217-222
1990
ISSN/ISBN: 0393-1978 PMID: 2147124 Document Number: 365037
Purpose of the study was to investigate whether and to what extent blood pressure variability and average night-time blood pressure are related to cardiovascular complications in hypertension. To this aim 60 normotensive and 462 hypertensive subjects were studied by means of non-invasive 24 hour blood pressure monitoring, using either the Avionics, or the ICR Spacelabs, or the Takeda system. Each subject was attributed a target organ damage score on the basis of 12-lead electrocardiogram, chest X-ray and fundoscopy, starting from 0 (no damage) up to 5 (maximum degree of damage). The 522 subjects were subsequently subdivided into 5 classes of increasing average daytime diastolic blood pressure. In each class a higher degree of cardiovascular complications was present in the subjects with the higher blood pressure variability and the higher average night-time blood pressure. From these results it may be inferred that both blood pressure variability and night-time blood pressure are related to the degree of target organ damage in hypertension. This stresses the importance of recording blood pressure throughout the 24 hours.