Genetic epidemiology of non-insulin-dependent diabetes mellitus (NIDDM) in north India: distribution of Gm and Km allotypes in 'Punjabis'
Gill, P.S.; Pandey, J.P.; Blangero, J.; Corruccini, R.S.; Gill, I.S.
Disease Markers 8(2): 59-67
1990
ISSN/ISBN: 0278-0240 PMID: 2387125 Document Number: 363814
Non-insulin dependent diabetes mellitus (NIDDM) is becoming endemic to modernizing and urbanizing populations all over the globe. The data on Gm and Km allotypes in the 'Punjabis' (n = 165) from north India show an interesting association with NIDDM. Differences between diabetic and control samples for the Km allele frequency distribution approach significance (p = 0.0897). The observed phenotypic diversity in the Gm system in diabetics indicates genetic heterogeneity in the disease group. A significant decrease (or absence) of phenotype Gm1,3,17; ;5,21 (p = 0.0119), and presence of phenotype Gm1,2,3,17; ;5,21 (p = 0.0158) in diabetics may constitute a risk factor for this disorder in 'Punjabis'.